Top Studies on Anti-Aging Benefits (2025 Update)

In the quest for longevity, NMN (Nicotinamide Mononucleotide) has emerged as a promising supplement for boosting NAD+ levels, which naturally decline with age and are linked to energy production, DNA repair, and cellular health. As research evolves, human trials are shedding light on its potential anti-aging effects, from improved endurance to better metabolic function. While animal studies show strong results, human data is building—here's a look at top studies up to 2025. Remember, these are for informational purposes; consult a healthcare professional before starting supplements. At SellHealth.store, our REJUVE® NMN is inspired by this science, offering high-purity options for UK users.

Why NMN? A Quick Primer on the Science

NMN is a precursor to NAD+, a coenzyme vital for mitochondrial function and sirtuin activation—key players in anti-aging. Declining NAD+ contributes to fatigue, cognitive fog, and metabolic issues. Trials suggest NMN supplementation can restore levels, potentially slowing biological aging. Below, we highlight landmark human studies, focusing on methods, results, and implications.

1. Uthever NMN Trial: Boosting NAD+ in Middle-Aged Adults (2022)

This multicentre, randomised, double-blind, placebo-controlled study tested 300mg daily NMN for 60 days in 66 adults aged 40-65.

• Methods: Participants took NMN or placebo after breakfast; assessed NAD+/NADH levels, 6-minute walk test, SF-36 quality-of-life scores, and HOMA-IR for insulin sensitivity.
• Key Results: NAD+/NADH rose 11.3% at day 30 and 38% at day 60 in the NMN group (vs. 0% and 14.3% in placebo). Walking endurance improved 6.5% (vs. 3.9%), SF-36 scores up 6.5% (vs. 3.4%), and HOMA-IR stayed stable (+0.6% vs. +30.6% rise in placebo). No serious side effects; mild events in 3.2% of both groups.
• Implications: Suggests NMN enhances energy and anti-aging markers, though differences weren't statistically significant—calling for larger trials.
• Citation: Huang H. (2022). Frontiers in Aging. doi: 10.3389/fragi.2022.851698.

2. NMN for Muscle Function in Healthy Older Men (2022)

A 12-week randomised, placebo-controlled trial examined 250mg daily NMN in healthy men aged 65+.

• Methods: Double-blind design; measured NAD+ levels, gait speed, grip strength, and safety.
• Key Results: NMN raised whole-blood NAD+ and showed partial gains in muscle performance, like improved gait speed and grip strength. Well-tolerated with no severe adverse events.
• Implications: Points to NMN's role in supporting physical function in aging, aligning with NAD+ restoration for mobility.
• Citation: Igarashi et al. (2022). npj Aging. doi: 10.1038/s41514-022-00084-z.

3. NMN in Older Adults with Diabetes (2023)

This 24-week placebo-controlled study tested 250mg daily NMN in older men with diabetes and reduced physical performance.

• Methods: Double-blind; focused on grip strength, walking speed, frailty, and tolerability.
• Key Results: Safe with no severe events; trend toward lower frailty in NMN group, but no significant improvements in strength or speed vs. placebo.
• Implications: Highlights safety in at-risk groups, with hints at anti-frailty benefits—useful for metabolic anti-aging.
• Citation: Akasaka et al. (2023). Geriatrics & Gerontology International. doi: 10.1111/ggi.14513.

4. Cel System Combo Supplement Trial: Strength and Biological Age (2025)

A year-long study of the Cel System stack (including NMN in Cel2) in 51 adults aged 54-84.

• Methods: Daily supplementation; measured grip strength, chair stands, body composition, and epigenetic clocks (Horvath, PhenoAge, GrimAge) at 3, 6, and 12 months.
• Key Results: Significant improvements in strength and chair stands at 6-12 months; reduced biological age via methylation changes in genes for inflammation, mitochondria, and repair. NMN noted for NAD+ boosting to aid endurance and mitochondrial health.
• Implications: Combo approaches with NMN may slow aging markers, emphasizing holistic supplementation.
• Citation: Carreras-Gallo et al. (2025). Aging. https://www.aging-us.com/article/206221/text.

Emerging Trends and Limitations

Recent reviews note NMN's safety across trials, with doses up to 1,200mg well-tolerated, but human results vary—some show NAD+ boosts without full anti-aging effects due to small samples or short durations. Ongoing studies (e.g., on cardiometabolic function) aim to clarify. Limitations include statistical non-significance in some outcomes and the need for larger, longer trials.

FAQs

• What do studies say about NMN safety? Trials show it's well-tolerated up to 1,200mg daily, with minimal side effects.
• How soon do benefits appear? NAD+ increases seen in 30-60 days; physical gains in 12+ weeks.
• Is NMN effective for anti-aging? Promising for NAD+ and metabolism, but more research needed for full effects.
• UK regulations? Legal as a supplement; choose FSA-compliant brands like REJUVE®.

Conclusion

These studies underscore NMN's potential in anti-aging, from NAD+ elevation to enhanced vitality. At SellHealth.store, our lab-tested REJUVE® NMN draws from this evidence—start with 500mg capsules for your routine. For partnerships, contact us! Always seek GP advice per NHS guidelines.